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Cholesterol promotes clustering of PI(4,5)P(2) driving unconventional secretion of FGF2
FGF2 is a cell survival factor involved in tumor-induced angiogenesis that is secreted through an unconventional secretory pathway based upon direct protein translocation across the plasma membrane. Here, we demonstrate that both PI(4,5)P(2)-dependent FGF2 recruitment at the inner plasma membrane le...
Autores principales: | Lolicato, Fabio, Saleppico, Roberto, Griffo, Alessandra, Meyer, Annalena, Scollo, Federica, Pokrandt, Bianca, Müller, Hans-Michael, Ewers, Helge, Hähl, Hendrik, Fleury, Jean-Baptiste, Seemann, Ralf, Hof, Martin, Brügger, Britta, Jacobs, Karin, Vattulainen, Ilpo, Nickel, Walter |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Rockefeller University Press
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9526255/ https://www.ncbi.nlm.nih.gov/pubmed/36173379 http://dx.doi.org/10.1083/jcb.202106123 |
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