T cell receptor dynamic and transcriptional determinants of T cell expansion in glioma-infiltrating T cells

BACKGROUND: Glioblastoma (GBM) is characterized by low numbers of glioma-infiltrating lymphocytes (GIL) with a dysfunctional phenotype. Whether this dysfunctional phenotype is fixed or can be reversed upon ex vivo culturing is poorly understood. The aim of this study was to assess T cell receptor (T...

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Detalles Bibliográficos
Autores principales: Lu, Kevin Hai-Ning, Michel, Julius, Kilian, Michael, Aslan, Katrin, Qi, Hao, Kehl, Niklas, Jung, Stefanie, Sanghvi, Khwab, Lindner, Katharina, Zhang, Xin-Wen, Green, Edward W, Poschke, Isabel, Ratliff, Miriam, Bunse, Theresa, Sahm, Felix, von Deimling, Andreas, Wick, Wolfgang, Platten, Michael, Bunse, Lukas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Basic and Translational Investigations
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9526356/
https://www.ncbi.nlm.nih.gov/pubmed/36196364
http://dx.doi.org/10.1093/noajnl/vdac140

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9526356/
https://www.ncbi.nlm.nih.gov/pubmed/36196364
http://dx.doi.org/10.1093/noajnl/vdac140

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