BRCA1 overexpression attenuates breast cancer cell growth and migration by regulating the pyruvate kinase M2-mediated Warburg effect via the PI3K/AKT signaling pathway

This work explored the mechanism of the effect of breast-cancer susceptibility gene 1 (BRCA1) on the metabolic characteristics of breast cancer cells, including the Warburg effect and its specific signaling. We transfected MCF-7 cells with a BRCA1-encoding LXSN plasmid or PKM2 siRNA and examined can...

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Detalles Bibliográficos
Autores principales: Liu, Xiuli, Liu, Hanxu, Zeng, Lei, Lv, Yuetao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2022
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9526413/
https://www.ncbi.nlm.nih.gov/pubmed/36193432
http://dx.doi.org/10.7717/peerj.14052

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9526413/
https://www.ncbi.nlm.nih.gov/pubmed/36193432
http://dx.doi.org/10.7717/peerj.14052

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