Energy landscape reshaped by strain-specific mutations underlies epistasis in NS1 evolution of influenza A virus

Elucidating how individual mutations affect the protein energy landscape is crucial for understanding how proteins evolve. However, predicting mutational effects remains challenging because of epistasis—the nonadditive interactions between mutations. Here, we investigate the biophysical mechanism of...

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Detalles Bibliográficos
Autores principales: Kim, Iktae, Dubrow, Alyssa, Zuniga, Bryan, Zhao, Baoyu, Sherer, Noah, Bastiray, Abhishek, Li, Pingwei, Cho, Jae-Hyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9526705/
https://www.ncbi.nlm.nih.gov/pubmed/36182933
http://dx.doi.org/10.1038/s41467-022-33554-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9526705/
https://www.ncbi.nlm.nih.gov/pubmed/36182933
http://dx.doi.org/10.1038/s41467-022-33554-9

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