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Energy landscape reshaped by strain-specific mutations underlies epistasis in NS1 evolution of influenza A virus
Elucidating how individual mutations affect the protein energy landscape is crucial for understanding how proteins evolve. However, predicting mutational effects remains challenging because of epistasis—the nonadditive interactions between mutations. Here, we investigate the biophysical mechanism of...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9526705/ https://www.ncbi.nlm.nih.gov/pubmed/36182933 http://dx.doi.org/10.1038/s41467-022-33554-9 |