Chemical screen uncovers novel structural classes of inhibitors of the papain-like protease of coronaviruses

The papain-like protease (PLpro) of coronaviruses is an attractive antiviral target to inhibit both viral replication and interference of the host immune response. We have identified and characterized three novel classes of small molecules, thiophene, cyanofuran, and triazoloquinazoline, as PLpro in...

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Detalles Bibliográficos
Autores principales: Jeong, Kwiwan, Kim, Jinhee, Chang, JuOae, Hong, Subin, Kim, Inseo, Oh, Sunghyun, Jeon, Sangeun, Lee, Joo Chan, Park, Hyun-Ju, Kim, Seungtaek, Lee, Wonsik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9526870/
https://www.ncbi.nlm.nih.gov/pubmed/36213008
http://dx.doi.org/10.1016/j.isci.2022.105254

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9526870/
https://www.ncbi.nlm.nih.gov/pubmed/36213008
http://dx.doi.org/10.1016/j.isci.2022.105254

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