Protocol for high-throughput screening of SARS-CoV-2 main protease inhibitors using a robust fluorescence polarization assay

Discovery of efficacious antiviral agents targeting SARS-CoV-2 main protease (Mpro) is of the highest importance to fight against COVID-19. Here, we describe a simple protocol for high-throughput screening of Mpro inhibitors using a robust fluorescence polarization (FP) assay. Candidate Mpro inhibit...

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Detalles Bibliográficos
Autores principales: Zhang, Jing, Yan, Haohao, Yan, Gangan, Liu, Xiaoping, Wang, Yanchang, Chen, Yunyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Protocol
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9527224/
https://www.ncbi.nlm.nih.gov/pubmed/36317181
http://dx.doi.org/10.1016/j.xpro.2022.101794

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9527224/
https://www.ncbi.nlm.nih.gov/pubmed/36317181
http://dx.doi.org/10.1016/j.xpro.2022.101794

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