Histone chaperone ASF1A accelerates chronic myeloid leukemia blast crisis by activating Notch signaling

The blast crisis (BC) is the final deadly phase of chronic myeloid leukemia (CML), which remains a major challenge in clinical management. However, the underlying molecular mechanism driving blastic transformation remains unclear. Here, we show that ASF1A, an essential activator, enhanced the transf...

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Detalles Bibliográficos
Autores principales: Yin, Xiaolin, Zhou, Minran, Zhang, Lu, Fu, Yue, Xu, Man, Wang, Xiaoming, Cui, Zelong, Gao, Zhenxing, Li, Miao, Dong, Yuting, Feng, Huimin, Ma, Sai, Chen, Chunyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9527247/
https://www.ncbi.nlm.nih.gov/pubmed/36184659
http://dx.doi.org/10.1038/s41419-022-05234-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9527247/
https://www.ncbi.nlm.nih.gov/pubmed/36184659
http://dx.doi.org/10.1038/s41419-022-05234-5

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