XPF activates break-induced telomere synthesis

Alternative Lengthening of Telomeres (ALT) utilizes a recombination mechanism and break-induced DNA synthesis to maintain telomere length without telomerase, but it is unclear how cells initiate ALT. TERRA, telomeric repeat-containing RNA, forms RNA:DNA hybrids (R-loops) at ALT telomeres. We show th...

Descripción completa

Detalles Bibliográficos
Autores principales: Guh, Chia-Yu, Shen, Hong-Jhih, Chen, Liv WeiChien, Chiu, Pei-Chen, Liao, I-Hsin, Lo, Chen-Chia, Chen, Yunfei, Hsieh, Yu-Hung, Chang, Ting-Chia, Yen, Chien-Ping, Chen, Yi-Yun, Chen, Tom Wei-Wu, Chen, Liuh-Yow, Wu, Ching-Shyi, Egly, Jean-Marc, Chu, Hsueh-Ping Catherine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9527253/
https://www.ncbi.nlm.nih.gov/pubmed/36184605
http://dx.doi.org/10.1038/s41467-022-33428-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9527253/
https://www.ncbi.nlm.nih.gov/pubmed/36184605
http://dx.doi.org/10.1038/s41467-022-33428-0

Ejemplares similares