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XPF activates break-induced telomere synthesis

Alternative Lengthening of Telomeres (ALT) utilizes a recombination mechanism and break-induced DNA synthesis to maintain telomere length without telomerase, but it is unclear how cells initiate ALT. TERRA, telomeric repeat-containing RNA, forms RNA:DNA hybrids (R-loops) at ALT telomeres. We show th...

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Detalles Bibliográficos
Autores principales:	Guh, Chia-Yu, Shen, Hong-Jhih, Chen, Liv WeiChien, Chiu, Pei-Chen, Liao, I-Hsin, Lo, Chen-Chia, Chen, Yunfei, Hsieh, Yu-Hung, Chang, Ting-Chia, Yen, Chien-Ping, Chen, Yi-Yun, Chen, Tom Wei-Wu, Chen, Liuh-Yow, Wu, Ching-Shyi, Egly, Jean-Marc, Chu, Hsueh-Ping Catherine
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9527253/ https://www.ncbi.nlm.nih.gov/pubmed/36184605 http://dx.doi.org/10.1038/s41467-022-33428-0

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