The design and evaluation of hybrid controlled trials that leverage external data and randomization

Patient-level data from completed clinical studies or electronic health records can be used in the design and analysis of clinical trials. However, these external data can bias the evaluation of the experimental treatment when the statistical design does not appropriately account for potential confo...

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Detalles Bibliográficos
Autores principales: Ventz, Steffen, Khozin, Sean, Louv, Bill, Sands, Jacob, Wen, Patrick Y., Rahman, Rifaquat, Comment, Leah, Alexander, Brian M., Trippa, Lorenzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9527257/
https://www.ncbi.nlm.nih.gov/pubmed/36184621
http://dx.doi.org/10.1038/s41467-022-33192-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9527257/
https://www.ncbi.nlm.nih.gov/pubmed/36184621
http://dx.doi.org/10.1038/s41467-022-33192-1

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