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The design and evaluation of hybrid controlled trials that leverage external data and randomization
Patient-level data from completed clinical studies or electronic health records can be used in the design and analysis of clinical trials. However, these external data can bias the evaluation of the experimental treatment when the statistical design does not appropriately account for potential confo...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9527257/ https://www.ncbi.nlm.nih.gov/pubmed/36184621 http://dx.doi.org/10.1038/s41467-022-33192-1 |