Cargando…

Effects of exercise intensity and frequency on improving cognitive performance in middle-aged and older adults with mild cognitive impairment: A pilot randomized controlled trial on the minimum physical activity recommendation from WHO

Background: The World Health Organization physical activity guidelines recommend adults and older adults to accumulate at least 150–300 min of moderate or 75–150 min of vigorous aerobic-type physical activity weekly for health benefits including improvements of cognitive performance. However, the op...

Descripción completa

Detalles Bibliográficos
Autores principales: Yu, Danny J., Yu, Angus P., Bernal, Joshua D. K., Fong, Daniel Y., Chan, Derwin K. C., Cheng, Calvin P., Siu, Parco M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9527311/
https://www.ncbi.nlm.nih.gov/pubmed/36200056
http://dx.doi.org/10.3389/fphys.2022.1021428
_version_ 1784801056671137792
author Yu, Danny J.
Yu, Angus P.
Bernal, Joshua D. K.
Fong, Daniel Y.
Chan, Derwin K. C.
Cheng, Calvin P.
Siu, Parco M.
author_facet Yu, Danny J.
Yu, Angus P.
Bernal, Joshua D. K.
Fong, Daniel Y.
Chan, Derwin K. C.
Cheng, Calvin P.
Siu, Parco M.
author_sort Yu, Danny J.
collection PubMed
description Background: The World Health Organization physical activity guidelines recommend adults and older adults to accumulate at least 150–300 min of moderate or 75–150 min of vigorous aerobic-type physical activity weekly for health benefits including improvements of cognitive performance. However, the optimal exercise intensity and frequency for maximizing the cognitive benefits remain unclear. Purpose: We conducted a parallel, assessor-blinded, pilot randomized controlled trial to evaluate the effectiveness of different intensities and frequencies of the WHO-recommended minimal volume of aerobic-type physical activity on improving cognitive performance in middle-aged and older adults with mild cognitive impairment (MCI). Methods: Participants were randomly allocated to the stretching exercise control group (CON), once-a-week and thrice-a-week moderate-intensity walking groups (M1 and M3), and once-a-week and thrice-a-week vigorous-intensity walking groups (V1 and V3). Intervention duration was 12 weeks. The primary outcome was global cognitive performance assessed by the Hong Kong version of Montreal Cognitive Assessment. Secondary outcomes were self-report and objective cognitive performances, mental health, sleep quality, and cardiorespiratory fitness. Results: Thirty-seven participants completed the study (CON: n = 7, M1: n = 7, M3: n = 7, V1: n = 8, V3: n = 8). Participants in all four walking exercise groups demonstrated significant improvements in global cognitive performance assessed by the Hong Kong version of the Montreal Cognitive Assessment after the intervention when compared to CON (p < 0.001). The walking exercise interventions also significantly mitigated the anxiety severity (p < 0.005) and improved the cardiorespiratory fitness (p < 0.05) of the participants in the walking exercise groups. Conclusion: 150-min moderate- or 75-min vigorous-intensity walking exercise performed once- or thrice-weekly showed similar effects on improving cognitive performance in middle-aged and older adults with MCI. The 12-week walking exercise interventions also reduced anxiety severity and improved cardiorespiratory fitness of the participants. Clinical Trial Registration: clinicaltrials.gov, identifier NCT04515563
format Online
Article
Text
id pubmed-9527311
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-95273112022-10-04 Effects of exercise intensity and frequency on improving cognitive performance in middle-aged and older adults with mild cognitive impairment: A pilot randomized controlled trial on the minimum physical activity recommendation from WHO Yu, Danny J. Yu, Angus P. Bernal, Joshua D. K. Fong, Daniel Y. Chan, Derwin K. C. Cheng, Calvin P. Siu, Parco M. Front Physiol Physiology Background: The World Health Organization physical activity guidelines recommend adults and older adults to accumulate at least 150–300 min of moderate or 75–150 min of vigorous aerobic-type physical activity weekly for health benefits including improvements of cognitive performance. However, the optimal exercise intensity and frequency for maximizing the cognitive benefits remain unclear. Purpose: We conducted a parallel, assessor-blinded, pilot randomized controlled trial to evaluate the effectiveness of different intensities and frequencies of the WHO-recommended minimal volume of aerobic-type physical activity on improving cognitive performance in middle-aged and older adults with mild cognitive impairment (MCI). Methods: Participants were randomly allocated to the stretching exercise control group (CON), once-a-week and thrice-a-week moderate-intensity walking groups (M1 and M3), and once-a-week and thrice-a-week vigorous-intensity walking groups (V1 and V3). Intervention duration was 12 weeks. The primary outcome was global cognitive performance assessed by the Hong Kong version of Montreal Cognitive Assessment. Secondary outcomes were self-report and objective cognitive performances, mental health, sleep quality, and cardiorespiratory fitness. Results: Thirty-seven participants completed the study (CON: n = 7, M1: n = 7, M3: n = 7, V1: n = 8, V3: n = 8). Participants in all four walking exercise groups demonstrated significant improvements in global cognitive performance assessed by the Hong Kong version of the Montreal Cognitive Assessment after the intervention when compared to CON (p < 0.001). The walking exercise interventions also significantly mitigated the anxiety severity (p < 0.005) and improved the cardiorespiratory fitness (p < 0.05) of the participants in the walking exercise groups. Conclusion: 150-min moderate- or 75-min vigorous-intensity walking exercise performed once- or thrice-weekly showed similar effects on improving cognitive performance in middle-aged and older adults with MCI. The 12-week walking exercise interventions also reduced anxiety severity and improved cardiorespiratory fitness of the participants. Clinical Trial Registration: clinicaltrials.gov, identifier NCT04515563 Frontiers Media S.A. 2022-09-19 /pmc/articles/PMC9527311/ /pubmed/36200056 http://dx.doi.org/10.3389/fphys.2022.1021428 Text en Copyright © 2022 Yu, Yu, Bernal, Fong, Chan, Cheng and Siu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Yu, Danny J.
Yu, Angus P.
Bernal, Joshua D. K.
Fong, Daniel Y.
Chan, Derwin K. C.
Cheng, Calvin P.
Siu, Parco M.
Effects of exercise intensity and frequency on improving cognitive performance in middle-aged and older adults with mild cognitive impairment: A pilot randomized controlled trial on the minimum physical activity recommendation from WHO
title Effects of exercise intensity and frequency on improving cognitive performance in middle-aged and older adults with mild cognitive impairment: A pilot randomized controlled trial on the minimum physical activity recommendation from WHO
title_full Effects of exercise intensity and frequency on improving cognitive performance in middle-aged and older adults with mild cognitive impairment: A pilot randomized controlled trial on the minimum physical activity recommendation from WHO
title_fullStr Effects of exercise intensity and frequency on improving cognitive performance in middle-aged and older adults with mild cognitive impairment: A pilot randomized controlled trial on the minimum physical activity recommendation from WHO
title_full_unstemmed Effects of exercise intensity and frequency on improving cognitive performance in middle-aged and older adults with mild cognitive impairment: A pilot randomized controlled trial on the minimum physical activity recommendation from WHO
title_short Effects of exercise intensity and frequency on improving cognitive performance in middle-aged and older adults with mild cognitive impairment: A pilot randomized controlled trial on the minimum physical activity recommendation from WHO
title_sort effects of exercise intensity and frequency on improving cognitive performance in middle-aged and older adults with mild cognitive impairment: a pilot randomized controlled trial on the minimum physical activity recommendation from who
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9527311/
https://www.ncbi.nlm.nih.gov/pubmed/36200056
http://dx.doi.org/10.3389/fphys.2022.1021428
work_keys_str_mv AT yudannyj effectsofexerciseintensityandfrequencyonimprovingcognitiveperformanceinmiddleagedandolderadultswithmildcognitiveimpairmentapilotrandomizedcontrolledtrialontheminimumphysicalactivityrecommendationfromwho
AT yuangusp effectsofexerciseintensityandfrequencyonimprovingcognitiveperformanceinmiddleagedandolderadultswithmildcognitiveimpairmentapilotrandomizedcontrolledtrialontheminimumphysicalactivityrecommendationfromwho
AT bernaljoshuadk effectsofexerciseintensityandfrequencyonimprovingcognitiveperformanceinmiddleagedandolderadultswithmildcognitiveimpairmentapilotrandomizedcontrolledtrialontheminimumphysicalactivityrecommendationfromwho
AT fongdaniely effectsofexerciseintensityandfrequencyonimprovingcognitiveperformanceinmiddleagedandolderadultswithmildcognitiveimpairmentapilotrandomizedcontrolledtrialontheminimumphysicalactivityrecommendationfromwho
AT chanderwinkc effectsofexerciseintensityandfrequencyonimprovingcognitiveperformanceinmiddleagedandolderadultswithmildcognitiveimpairmentapilotrandomizedcontrolledtrialontheminimumphysicalactivityrecommendationfromwho
AT chengcalvinp effectsofexerciseintensityandfrequencyonimprovingcognitiveperformanceinmiddleagedandolderadultswithmildcognitiveimpairmentapilotrandomizedcontrolledtrialontheminimumphysicalactivityrecommendationfromwho
AT siuparcom effectsofexerciseintensityandfrequencyonimprovingcognitiveperformanceinmiddleagedandolderadultswithmildcognitiveimpairmentapilotrandomizedcontrolledtrialontheminimumphysicalactivityrecommendationfromwho