Systemic lupus erythematosus variants modulate the function of an enhancer upstream of TNFAIP3

TNFAIP3/A20 is a prominent autoimmune disease risk locus that is correlated with hypomorphic TNFAIP3 expression and exhibits complex chromatin architecture with over 30 predicted enhancers. This study aimed to functionally characterize an enhancer ∼55 kb upstream of the TNFAIP3 promoter marked by th...

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Detalles Bibliográficos
Autores principales: Pasula, Satish, Gopalakrishnan, Jaanam, Fu, Yao, Tessneer, Kandice L., Wiley, Mandi M., Pelikan, Richard C., Kelly, Jennifer A., Gaffney, Patrick M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9527318/
https://www.ncbi.nlm.nih.gov/pubmed/36199584
http://dx.doi.org/10.3389/fgene.2022.1011965

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9527318/
https://www.ncbi.nlm.nih.gov/pubmed/36199584
http://dx.doi.org/10.3389/fgene.2022.1011965

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