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Systemic lupus erythematosus variants modulate the function of an enhancer upstream of TNFAIP3

TNFAIP3/A20 is a prominent autoimmune disease risk locus that is correlated with hypomorphic TNFAIP3 expression and exhibits complex chromatin architecture with over 30 predicted enhancers. This study aimed to functionally characterize an enhancer ∼55 kb upstream of the TNFAIP3 promoter marked by th...

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Detalles Bibliográficos
Autores principales:	Pasula, Satish, Gopalakrishnan, Jaanam, Fu, Yao, Tessneer, Kandice L., Wiley, Mandi M., Pelikan, Richard C., Kelly, Jennifer A., Gaffney, Patrick M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Genetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9527318/ https://www.ncbi.nlm.nih.gov/pubmed/36199584 http://dx.doi.org/10.3389/fgene.2022.1011965

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