Cargando…

Pregabalin Treatment does not Affect Amyloid Pathology in 5XFAD Mice

BACKGROUND: Calcium dysregulation has been proposed to play a causative role in the development of Alzheimer’s disease pathology. Pregabalin is a compound already approved for human use, marketed as the prescription drug Lyrica. It binds the α2-δ subunit of P/Q-type voltage-gated calcium channels, l...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sadleir, Katherine R., Popovoic, Jelena, Zhu, Wei, Reidel, Cory T., Do, Ha, Silverman, Richard B., Vassar, Robert
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9527523/ https://www.ncbi.nlm.nih.gov/pubmed/34259145 http://dx.doi.org/10.2174/1567205018666210713125333

Ejemplares similares

Oral nimodipine treatment has no effect on amyloid pathology or neuritic dystrophy in the 5XFAD mouse model of amyloidosis
por: Sadleir, Katherine R., et al.
Publicado: (2022)

ER stress is not elevated in the 5XFAD mouse model of Alzheimer's disease
por: Sadleir, Katherine R., et al.
Publicado: (2018)

Aβ reduction in BACE1 heterozygous null 5XFAD mice is associated with transgenic APP level
por: Sadleir, Katherine R, et al.
Publicado: (2015)

Jowiseungchungtang Inhibits Amyloid-β Aggregation and Amyloid-β-Mediated Pathology in 5XFAD Mice
por: Shin, Soo Jung, et al.
Publicado: (2018)

Genetic Inhibition of Phosphorylation of the Translation Initiation Factor eIF2α Does Not Block Aβ-Dependent Elevation of BACE1 and APP Levels or Reduce Amyloid Pathology in a Mouse Model of Alzheimer’s Disease
por: Sadleir, Katherine R., et al.
Publicado: (2014)

Connections between ApoE, sleep, and Aβ and tau pathologies in Alzheimer’s disease
por: Sadleir, Katherine R., et al.
Publicado: (2023)

Physiological expression of mutated TAU impaired astrocyte activity and exacerbates β-amyloid pathology in 5xFAD mice
por: Farfara, Dorit, et al.
Publicado: (2023)

Sleeve Gastrectomy Reduces Glycemia but Does Not Affect Cognitive Impairment in Lean 5xFAD Mice
por: Samuel, Itia, et al.
Publicado: (2022)

Donepezil ameliorates Aβ pathology but not tau pathology in 5xFAD mice
por: Choi, Hee-Jeong, et al.
Publicado: (2022)

Brain Region-Specific Differences in Amyloid-β Plaque Composition in 5XFAD Mice
por: Bader, Angelika Sabine, et al.
Publicado: (2023)

High-dose of vitamin C supplementation reduces amyloid plaque burden and ameliorates pathological changes in the brain of 5XFAD mice
por: Kook, S-Y, et al.
Publicado: (2014)

Carprofen alleviates Alzheimer-like phenotypes of 5XFAD transgenic mice by targeting the pathological hallmarks induced by amyloid-β aggregation
por: Lee, Donghee, et al.
Publicado: (2023)

MK-0677, a Ghrelin Agonist, Alleviates Amyloid Beta-Related Pathology in 5XFAD Mice, an Animal Model of Alzheimer’s Disease
por: Jeong, Yu-on, et al.
Publicado: (2018)

Plasma Rich in Growth Factors (PRGF) Disrupt the Blood-Brain Barrier Integrity and Elevate Amyloid Pathology in the Brains of 5XFAD Mice
por: Duong, Quoc-Viet, et al.
Publicado: (2019)

The VEGF inhibitor vatalanib regulates AD pathology in 5xFAD mice
por: Jeon, Seong Gak, et al.
Publicado: (2020)

Inhibition of Colony-Stimulating Factor 1 Receptor by PLX3397 Prevents Amyloid Beta Pathology and Rescues Dopaminergic Signaling in Aging 5xFAD Mice
por: Son, Yeonghoon, et al.
Publicado: (2020)

Intravenous Injection of PHF-Tau Proteins From Alzheimer Brain Exacerbates Neuroinflammation, Amyloid Beta, and Tau Pathologies in 5XFAD Transgenic Mice
por: Houben, Sarah, et al.
Publicado: (2020)

(-)-Oleocanthal Nutraceuticals for Alzheimer’s Disease Amyloid Pathology: Novel Oral Formulations, Therapeutic, and Molecular Insights in 5xFAD Transgenic Mice Model
por: Tajmim, Afsana, et al.
Publicado: (2021)

Cyclopentanone Derivative Attenuates Memory Impairment by Inhibiting Amyloid Plaques Formation in the 5xFAD Mice
por: Ullah, Rahim, et al.
Publicado: (2021)

Transferrin-Conjugated Melittin-Loaded L-Arginine-Coated Iron Oxide Nanoparticles for Mitigating Beta-Amyloid Pathology of the 5XFAD Mouse Brain
por: Choi, Moonseok, et al.
Publicado: (2023)

Discovery and engineering of an anti-TREM2 antibody to promote amyloid plaque clearance by microglia in 5XFAD mice
por: Zhao, Peng, et al.
Publicado: (2022)

Impact of Gut Microbiome Manipulation in 5xFAD Mice on Alzheimer’s Disease-Like Pathology
por: Guilherme, Malena dos Santos, et al.
Publicado: (2021)

5XFAD Mice Show Early Onset Gap Detection Deficits
por: Kaylegian, Katherine, et al.
Publicado: (2019)

The Alzheimer’s β-secretase BACE1 localizes to normal presynaptic terminals and to dystrophic presynaptic terminals surrounding amyloid plaques
por: Kandalepas, Patty C., et al.
Publicado: (2013)

Erratum to: The Alzheimer’s β-secretase BACE1 localizes to normal presynaptic terminals and to dystrophic presynaptic terminals surrounding amyloid plaques
por: Kandalepas, Patty C., et al.
Publicado: (2013)

Evidence for Enhanced Efficacy of Passive Immunotherapy against Beta-Amyloid in CD33-Negative 5xFAD Mice
por: Gnoth, Kathrin, et al.
Publicado: (2022)

Neuron loss in the 5XFAD mouse model of Alzheimer’s disease correlates with intraneuronal Aβ(42) accumulation and Caspase-3 activation
por: Eimer, William A, et al.
Publicado: (2013)

Early Detection of Aβ Deposition in the 5xFAD Mouse by Amyloid PET
por: Oh, Se Jong, et al.
Publicado: (2018)

Presynaptic dystrophic neurites surrounding amyloid plaques are sites of microtubule disruption, BACE1 elevation, and increased Aβ generation in Alzheimer’s disease
por: Sadleir, Katherine R., et al.
Publicado: (2016)

Impact of the Age of Cecal Material Transfer Donors on Alzheimer’s Disease Pathology in 5xFAD Mice
por: Valeri, Francesco, et al.
Publicado: (2021)

BACE1 elevation engendered by GGA3 deletion increases β-amyloid pathology in association with APP elevation and decreased CHL1 processing in 5XFAD mice
por: Kim, WonHee, et al.
Publicado: (2018)

Inhibition of REV‐ERBs stimulates microglial amyloid‐beta clearance and reduces amyloid plaque deposition in the 5XFAD mouse model of Alzheimer’s disease
por: Lee, Jiyeon, et al.
Publicado: (2019)

Hippocampal disruptions of synaptic and astrocyte metabolism are primary events of early amyloid pathology in the 5xFAD mouse model of Alzheimer’s disease
por: Andersen, Jens V., et al.
Publicado: (2021)

Therapeutic Trem2 activation ameliorates amyloid-beta deposition and improves cognition in the 5XFAD model of amyloid deposition
por: Price, Brittani R., et al.
Publicado: (2020)

Trans-Cinnamaldehyde Alleviates Amyloid-Beta Pathogenesis via the SIRT1-PGC1α-PPARγ Pathway in 5XFAD Transgenic Mice
por: Do, Jimin, et al.
Publicado: (2020)

The absence of myelin basic protein promotes neuroinflammation and reduces amyloid β-protein accumulation in Tg-5xFAD mice
por: Ou-Yang, Ming-Hsuan, et al.
Publicado: (2013)

Region-specific amyloid-β accumulation in the olfactory system influences olfactory sensory neuronal dysfunction in 5xFAD mice
por: Son, Gowoon, et al.
Publicado: (2021)

Assessment of neurodegeneration and neuronal loss in aged 5XFAD mice
por: Zhang, Liansheng, et al.
Publicado: (2021)

Dry age-related macular degeneration like pathology in aged 5XFAD mice: Ultrastructure and microarray analysis
por: Park, Sung Wook, et al.
Publicado: (2017)

Dietary Wheat Amylase Trypsin Inhibitors Impact Alzheimer’s Disease Pathology in 5xFAD Model Mice
por: dos Santos Guilherme, Malena, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_q2plijrfj532ivecdnru2mb1fn