PF‐06409577 inhibits renal cyst progression by concurrently inhibiting the mTOR pathway and CFTR channel activity

Renal cyst development and expansion in autosomal dominant polycystic kidney disease (ADPKD) involves over‐proliferation of cyst‐lining epithelial cells and excessive cystic fluid secretion. While metformin effectively inhibits renal cyst growth in mouse models of ADPKD it exhibits low potency, and...

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Detalles Bibliográficos
Autores principales: Su, Limin, Yuan, Haoxing, Zhang, Haoran, Wang, Ruoqi, Fu, Kequan, Yin, Long, Ren, Ying, Liu, Hongli, Fang, Qian, Wang, Junqi, Guo, Dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9527591/
https://www.ncbi.nlm.nih.gov/pubmed/35748097
http://dx.doi.org/10.1002/2211-5463.13459

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9527591/
https://www.ncbi.nlm.nih.gov/pubmed/35748097
http://dx.doi.org/10.1002/2211-5463.13459

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