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Crystal structure of the Rho-associated coiled-coil kinase 2 inhibitor belumosudil bound to CK2α
The small molecule belumosudil was initially identified as a selective inhibitor of Rho-associated coiled-coil kinase 2 (ROCK2) and has recently been approved for the treatment of graft-versus-host disease. However, recent studies have shown that many of the phenotypes displayed upon treatment with...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
International Union of Crystallography
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9527651/ https://www.ncbi.nlm.nih.gov/pubmed/36189718 http://dx.doi.org/10.1107/S2053230X22008767 |