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High-throughput screen to identify compounds that prevent or target telomere loss in human cancer cells
Chromosome instability (CIN) is an early step in carcinogenesis that promotes tumor cell progression and resistance to therapy. Using plasmids integrated adjacent to telomeres, we have previously demonstrated that the sensitivity of subtelomeric regions to DNA double-strand breaks (DSBs) contributes...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Oxford University Press
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9527662/ https://www.ncbi.nlm.nih.gov/pubmed/36196242 http://dx.doi.org/10.1093/narcan/zcac029 |