Increased SERCA2a sub-cellular heterogeneity in right-ventricular heart failure inhibits excitation-contraction coupling and modulates arrhythmogenic dynamics

The intracellular calcium handling system of cardiomyocytes is responsible for controlling excitation-contraction coupling (ECC) and has been linked to pro-arrhythmogenic cellular phenomena in conditions such as heart failure (HF). SERCA2a, responsible for intracellular uptake, is a primary regulato...

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Detalles Bibliográficos
Autores principales: Holmes, M., Hurley, M. E., Sheard, T. M. D., Benson, A. P., Jayasinghe, I., Colman, M. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2022
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9527927/
https://www.ncbi.nlm.nih.gov/pubmed/36189801
http://dx.doi.org/10.1098/rstb.2021.0317

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9527927/
https://www.ncbi.nlm.nih.gov/pubmed/36189801
http://dx.doi.org/10.1098/rstb.2021.0317

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