Pathogenic variants damage cell composition and single cell transcription in cardiomyopathies

Pathogenic variants in genes that cause dilated (DCM) and arrhythmogenic cardiomyopathies (ACM) convey high risks for the development of heart failure through unknown mechanisms. Using single nucleus RNA sequencing (snRNAseq), we characterized the transcriptome of 880,000 nuclei from 18 control and...

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Detalles Bibliográficos
Autores principales: Reichart, Daniel, Lindberg, Eric L., Maatz, Henrike, Miranda, Antonio M.A., Viveiros, Anissa, Shvetsov, Nikolay, Gärtner, Anna, Nadelmann, Emily R., Lee, Michael, Kanemaru, Kazumasa, Ruiz-Orera, Jorge, Strohmenger, Viktoria, DeLaughter, Daniel M., Patone, Giannino, Zhang, Hao, Woehler, Andrew, Lippert, Christoph, Kim, Yuri, Adami, Eleonora, Gorham, Joshua M., Barnett, Sam N., Brown, Kemar, Buchan, Rachel J., Chowdhury, Rasheda A., Constantinou, Chrystalla, Cranley, James, Felkin, Leanne E., Fox, Henrik, Ghauri, Ahla, Gummert, Jan, Kanda, Masatoshi, Li, Ruoyan, Mach, Lukas, McDonough, Barbara, Samari, Sara, Shahriaran, Farnoush, Yapp, Clarence, Stanasiuk, Caroline, Theotokis, Pantazis I., Theis, Fabian J., van den Bogaerdt, Antoon, Wakimoto, Hiroko, Ware, James S., Worth, Catherine L., Barton, Paul J.R., Lee, Young-Ae, Teichmann, Sarah A., Milting, Hendrik, Noseda, Michela, Oudit, Gavin Y., Heinig, Matthias, Seidman, Jonathan G., Hubner, Norbert, Seidman, Christine E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9528698/
https://www.ncbi.nlm.nih.gov/pubmed/35926050
http://dx.doi.org/10.1126/science.abo1984

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9528698/
https://www.ncbi.nlm.nih.gov/pubmed/35926050
http://dx.doi.org/10.1126/science.abo1984

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