Single-cell transcriptomics identifies pathogenic T-helper 17.1 cells and pro-inflammatory monocytes in immune checkpoint inhibitor-related pneumonitis

BACKGROUND: Immune checkpoint inhibitor (ICI)-related pneumonitis is the most frequent fatal immune-related adverse event associated with programmed cell death protein-1/programmed death ligand-1 blockade. The pathophysiology however remains largely unknown, owing to limited and contradictory findin...

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Detalles Bibliográficos
Autores principales: Franken, Amelie, Van Mol, Pierre, Vanmassenhove, Sam, Donders, Elena, Schepers, Rogier, Van Brussel, Thomas, Dooms, Christophe, Yserbyt, Jonas, De Crem, Nico, Testelmans, Dries, De Wever, Walter, Nackaerts, Kristiaan, Vansteenkiste, Johan, Vos, Robin, Humblet-Baron, Stéphanie, Lambrechts, Diether, Wauters, Els
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2022
Materias:
Clinical/Translational Cancer Immunotherapy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9528720/
https://www.ncbi.nlm.nih.gov/pubmed/36171010
http://dx.doi.org/10.1136/jitc-2022-005323

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9528720/
https://www.ncbi.nlm.nih.gov/pubmed/36171010
http://dx.doi.org/10.1136/jitc-2022-005323

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