Discovery of compounds with viscosity-reducing effects on biopharmaceutical formulations with monoclonal antibodies

For the development of concentrated monoclonal antibody formulations for subcutaneous administration, the main challenge is the high viscosity of the solutions. To compensate for this, viscosity reducing agents are commonly used as excipients. Here, we applied two computational chemistry approaches...

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Detalles Bibliográficos
Autores principales: Proj, Matic, Zidar, Mitja, Lebar, Blaž, Strašek, Nika, Miličić, Goran, Žula, Aleš, Gobec, Stanislav
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9529560/
https://www.ncbi.nlm.nih.gov/pubmed/36212536
http://dx.doi.org/10.1016/j.csbj.2022.09.035

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9529560/
https://www.ncbi.nlm.nih.gov/pubmed/36212536
http://dx.doi.org/10.1016/j.csbj.2022.09.035

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