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Discovery of compounds with viscosity-reducing effects on biopharmaceutical formulations with monoclonal antibodies
For the development of concentrated monoclonal antibody formulations for subcutaneous administration, the main challenge is the high viscosity of the solutions. To compensate for this, viscosity reducing agents are commonly used as excipients. Here, we applied two computational chemistry approaches...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Research Network of Computational and Structural Biotechnology
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9529560/ https://www.ncbi.nlm.nih.gov/pubmed/36212536 http://dx.doi.org/10.1016/j.csbj.2022.09.035 |