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Protocol to use TopNet for gene regulatory network modeling using gene expression data from perturbation experiments

Inference of gene regulatory networks from gene perturbation experiments is the most reliable approach for investigating interdependence between genes. Here, we describe the initial gene perturbations, expression measurements, and preparation steps, followed by network modeling using TopNet. Summari...

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Detalles Bibliográficos
Autores principales: McMurray, Helene R., Stern, Harry A., Ambeskovic, Aslihan, Land, Hartmut, McCall, Matthew N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9529586/
https://www.ncbi.nlm.nih.gov/pubmed/36181678
http://dx.doi.org/10.1016/j.xpro.2022.101737