His‐163 is a stereospecific proton donor in the mechanism of d‐glucosaminate‐6‐phosphate ammonia‐lyase

d‐Glucosaminate‐6‐phosphate ammonia‐lyase (DGL) catalyzes the conversion of d‐glucosaminate‐6‐phosphate to 2‐keto‐3‐deoxyglutarate‐6‐phosphate, with stereospecific protonation of C‐3 of the product. The crystal structure of DGL showed that His‐163 could serve as the proton donor. H163A mutant DGL is...

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Detalles Bibliográficos
Autores principales: Phillips, Robert S., Anderson, Kaitlin L., Gresham, Declan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9529869/
https://www.ncbi.nlm.nih.gov/pubmed/35953460
http://dx.doi.org/10.1002/1873-3468.14469

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9529869/
https://www.ncbi.nlm.nih.gov/pubmed/35953460
http://dx.doi.org/10.1002/1873-3468.14469

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