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His‐163 is a stereospecific proton donor in the mechanism of d‐glucosaminate‐6‐phosphate ammonia‐lyase
d‐Glucosaminate‐6‐phosphate ammonia‐lyase (DGL) catalyzes the conversion of d‐glucosaminate‐6‐phosphate to 2‐keto‐3‐deoxyglutarate‐6‐phosphate, with stereospecific protonation of C‐3 of the product. The crystal structure of DGL showed that His‐163 could serve as the proton donor. H163A mutant DGL is...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9529869/ https://www.ncbi.nlm.nih.gov/pubmed/35953460 http://dx.doi.org/10.1002/1873-3468.14469 |