PD-L1 induction via the MEK-JNK-AP1 axis by a neddylation inhibitor promotes cancer-associated immunosuppression

MLN4924 is a first-in-class small molecule inhibitor of NEDD8-activating enzyme (NAE), which is currently in several clinical trials for anti-cancer applications. However, MLN4924 also showed some off-target effects with potential to promote the growth of cancer cells which counteracts its anticance...

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Detalles Bibliográficos
Autores principales: Zhang, Shizhen, You, Xiahong, Xu, Tiantian, Chen, Qian, Li, Hua, Dou, Longyu, Sun, Yilun, Xiong, Xiufang, Meredith, Morgan A., Sun, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9529958/
https://www.ncbi.nlm.nih.gov/pubmed/36192389
http://dx.doi.org/10.1038/s41419-022-05292-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9529958/
https://www.ncbi.nlm.nih.gov/pubmed/36192389
http://dx.doi.org/10.1038/s41419-022-05292-9

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