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Pharmacological basis of the antifibrotic effects of pirfenidone: Mechanistic insights from cardiac in-vitro and in-vivo models

Pirfenidone is a small drug with marked antifibrotic activity approved for the treatment of Idiopathic pulmonary fibrosis. Recently, its peculiar pharmacological profile has attracted attention for its potential therapeutic benefit for extra-pulmonary disorders characterized by pathological fibrosis...

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Detalles Bibliográficos
Autores principales: Sartiani, Laura, Bartolucci, Gianluca, Pallecchi, Marco, Spinelli, Valentina, Cerbai, Elisabetta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9530045/
https://www.ncbi.nlm.nih.gov/pubmed/36204580
http://dx.doi.org/10.3389/fcvm.2022.751499