De novo design of immunoglobulin-like domains

Antibodies, and antibody derivatives such as nanobodies, contain immunoglobulin-like (Ig) β-sandwich scaffolds which anchor the hypervariable antigen-binding loops and constitute the largest growing class of drugs. Current engineering strategies for this class of compounds rely on naturally existing...

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Detalles Bibliográficos
Autores principales: Chidyausiku, Tamuka M., Mendes, Soraia R., Klima, Jason C., Nadal, Marta, Eckhard, Ulrich, Roel-Touris, Jorge, Houliston, Scott, Guevara, Tibisay, Haddox, Hugh K., Moyer, Adam, Arrowsmith, Cheryl H., Gomis-Rüth, F. Xavier, Baker, David, Marcos, Enrique
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9530121/
https://www.ncbi.nlm.nih.gov/pubmed/36192397
http://dx.doi.org/10.1038/s41467-022-33004-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9530121/
https://www.ncbi.nlm.nih.gov/pubmed/36192397
http://dx.doi.org/10.1038/s41467-022-33004-6

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