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De novo design of immunoglobulin-like domains

Antibodies, and antibody derivatives such as nanobodies, contain immunoglobulin-like (Ig) β-sandwich scaffolds which anchor the hypervariable antigen-binding loops and constitute the largest growing class of drugs. Current engineering strategies for this class of compounds rely on naturally existing...

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Detalles Bibliográficos
Autores principales:	Chidyausiku, Tamuka M., Mendes, Soraia R., Klima, Jason C., Nadal, Marta, Eckhard, Ulrich, Roel-Touris, Jorge, Houliston, Scott, Guevara, Tibisay, Haddox, Hugh K., Moyer, Adam, Arrowsmith, Cheryl H., Gomis-Rüth, F. Xavier, Baker, David, Marcos, Enrique
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9530121/ https://www.ncbi.nlm.nih.gov/pubmed/36192397 http://dx.doi.org/10.1038/s41467-022-33004-6

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