Functional comparison of phosphomimetic S15D and T160D mutants of myosin regulatory light chain exchanged in cardiac muscle preparations of HCM and WT mice

In this study, we investigated the rescue potential of two phosphomimetic mutants of the myosin regulatory light chain (RLC, MYL2 gene), S15D, and T160D RLCs. S15D-RLC mimics phosphorylation of the established serine-15 site of the human cardiac RLC. T160D-RLC mimics the phosphorylation of threonine...

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Detalles Bibliográficos
Autores principales: Kazmierczak, Katarzyna, Liang, Jingsheng, Gomez-Guevara, Michelle, Szczesna-Cordary, Danuta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Cardiovascular Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9530205/
https://www.ncbi.nlm.nih.gov/pubmed/36204565
http://dx.doi.org/10.3389/fcvm.2022.988066

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9530205/
https://www.ncbi.nlm.nih.gov/pubmed/36204565
http://dx.doi.org/10.3389/fcvm.2022.988066

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