Tissue-specific impacts of aging and genetics on gene expression patterns in humans

Age is the primary risk factor for many common human diseases. Here, we quantify the relative contributions of genetics and aging to gene expression patterns across 27 tissues from 948 humans. We show that the predictive power of expression quantitative trait loci is impacted by age in many tissues....

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Detalles Bibliográficos
Autores principales: Yamamoto, Ryo, Chung, Ryan, Vazquez, Juan Manuel, Sheng, Huanjie, Steinberg, Philippa L., Ioannidis, Nilah M., Sudmant, Peter H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9530233/
https://www.ncbi.nlm.nih.gov/pubmed/36192477
http://dx.doi.org/10.1038/s41467-022-33509-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9530233/
https://www.ncbi.nlm.nih.gov/pubmed/36192477
http://dx.doi.org/10.1038/s41467-022-33509-0

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