Cryo-EM structure-based selection of computed ligand poses enables design of MTA-synergic PRMT5 inhibitors of better potency

Projected potential of 2.5–4.0 Å cryo-EM structures for structure-based drug design is not well realized yet. Here we show that a 3.1 Å structure of PRMT5 is suitable for selecting computed poses of a chemical inhibitor and its analogs for enhanced potency. PRMT5, an oncogenic target for various can...

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Detalles Bibliográficos
Autores principales: Zhou, Wei, Yadav, Gaya P., Yang, Xiaozhi, Qin, Feng, Li, Chenglong, Jiang, Qiu-Xing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9530242/
https://www.ncbi.nlm.nih.gov/pubmed/36192627
http://dx.doi.org/10.1038/s42003-022-03991-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9530242/
https://www.ncbi.nlm.nih.gov/pubmed/36192627
http://dx.doi.org/10.1038/s42003-022-03991-9

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