PGC1α overexpression preserves muscle mass and function in cisplatin‐induced cachexia

BACKGROUND: Chemotherapy induces a cachectic‐like phenotype, accompanied by skeletal muscle wasting, weakness and mitochondrial dysfunction. Peroxisome proliferator‐activated receptor‐gamma coactivator‐1 alpha (PGC1α), a regulator of mitochondrial biogenesis, is often reduced in cachectic skeletal m...

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Detalles Bibliográficos
Autores principales: Huot, Joshua R., Pin, Fabrizio, Chatterjee, Rohit, Bonetto, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9530502/
https://www.ncbi.nlm.nih.gov/pubmed/35903870
http://dx.doi.org/10.1002/jcsm.13035

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9530502/
https://www.ncbi.nlm.nih.gov/pubmed/35903870
http://dx.doi.org/10.1002/jcsm.13035

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