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PGC1α overexpression preserves muscle mass and function in cisplatin‐induced cachexia

BACKGROUND: Chemotherapy induces a cachectic‐like phenotype, accompanied by skeletal muscle wasting, weakness and mitochondrial dysfunction. Peroxisome proliferator‐activated receptor‐gamma coactivator‐1 alpha (PGC1α), a regulator of mitochondrial biogenesis, is often reduced in cachectic skeletal m...

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Detalles Bibliográficos
Autores principales:	Huot, Joshua R., Pin, Fabrizio, Chatterjee, Rohit, Bonetto, Andrea
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9530502/ https://www.ncbi.nlm.nih.gov/pubmed/35903870 http://dx.doi.org/10.1002/jcsm.13035

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