A multifaceted evaluation of microgliosis and differential cellular dysregulation of mammalian target of rapamycin signaling in neuronopathic Gaucher disease

Neuronopathic Gaucher disease (nGD) is an inherited neurodegenerative disease caused by mutations in GBA1 gene and is associated with premature death. Neuroinflammation plays a critical role in disease pathogenesis which is characterized by microgliosis, reactive astrocytosis, and neuron loss, altho...

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Detalles Bibliográficos
Autores principales: Zhang, Zhenting, Wang, Xiaohong, Lin, Yi, Pan, Dao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9530712/
https://www.ncbi.nlm.nih.gov/pubmed/36204141
http://dx.doi.org/10.3389/fnmol.2022.944883

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9530712/
https://www.ncbi.nlm.nih.gov/pubmed/36204141
http://dx.doi.org/10.3389/fnmol.2022.944883

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