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Effect of host genetics and gut microbiome on fat deposition traits in pigs

Fat deposition affects meat quality, flavor, and production in pigs. Fat deposition is influenced by both genetics and environment. Symbiotic microbe with the host is an important environmental factor to influence fat deposition. In this study, the fat deposition traits were measured in 239 individu...

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Autores principales: Wang, Yuan, Zhou, Ping, Zhou, Xiang, Fu, Ming, Wang, Tengfei, Liu, Zuhong, Liu, Xiaolei, Wang, Zhiquan, Liu, Bang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9530793/
https://www.ncbi.nlm.nih.gov/pubmed/36204621
http://dx.doi.org/10.3389/fmicb.2022.925200
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author Wang, Yuan
Zhou, Ping
Zhou, Xiang
Fu, Ming
Wang, Tengfei
Liu, Zuhong
Liu, Xiaolei
Wang, Zhiquan
Liu, Bang
author_facet Wang, Yuan
Zhou, Ping
Zhou, Xiang
Fu, Ming
Wang, Tengfei
Liu, Zuhong
Liu, Xiaolei
Wang, Zhiquan
Liu, Bang
author_sort Wang, Yuan
collection PubMed
description Fat deposition affects meat quality, flavor, and production in pigs. Fat deposition is influenced by both genetics and environment. Symbiotic microbe with the host is an important environmental factor to influence fat deposition. In this study, the fat deposition traits were measured in 239 individuals obtained from Tongcheng pigs × Large White pigs resource population. The interactions between genetics and gut microbiome in fat deposition traits were investigated through whole-genome sequencing and cecum microbial 16S ribosomal RNA sequencing. The results showed that the percentage of leaf fat (PL) and intramuscular fat content (IMF) were significantly influenced by host genetics–gut microbiome interaction. The effects of interactions between host genetics and gut microbiome on PL and IMF were 0.13 and 0.29, respectively. The heritability of PL and IMF was estimated as 0.71 and 0.89, respectively. The microbiability of PL and IMF was 0.20 and 0.26, respectively. Microbiome-wide association analysis (MWAS) revealed Anaeroplasma, Paraprevotella, Pasteurella, and Streptococcus were significantly associated with PL, and Sharpea and Helicobacter exhibited significant association with IMF (p < 0.05). Furthermore, Paraprevotella was also identified as a critical microbe affecting PL based on the divergent Wilcoxon rank-sum test. Overall, this study reveals the effect of host genetics and gut microbiome on pig fat deposition traits and provides a new perspective on the genetic improvement of pig fat deposition traits.
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spelling pubmed-95307932022-10-05 Effect of host genetics and gut microbiome on fat deposition traits in pigs Wang, Yuan Zhou, Ping Zhou, Xiang Fu, Ming Wang, Tengfei Liu, Zuhong Liu, Xiaolei Wang, Zhiquan Liu, Bang Front Microbiol Microbiology Fat deposition affects meat quality, flavor, and production in pigs. Fat deposition is influenced by both genetics and environment. Symbiotic microbe with the host is an important environmental factor to influence fat deposition. In this study, the fat deposition traits were measured in 239 individuals obtained from Tongcheng pigs × Large White pigs resource population. The interactions between genetics and gut microbiome in fat deposition traits were investigated through whole-genome sequencing and cecum microbial 16S ribosomal RNA sequencing. The results showed that the percentage of leaf fat (PL) and intramuscular fat content (IMF) were significantly influenced by host genetics–gut microbiome interaction. The effects of interactions between host genetics and gut microbiome on PL and IMF were 0.13 and 0.29, respectively. The heritability of PL and IMF was estimated as 0.71 and 0.89, respectively. The microbiability of PL and IMF was 0.20 and 0.26, respectively. Microbiome-wide association analysis (MWAS) revealed Anaeroplasma, Paraprevotella, Pasteurella, and Streptococcus were significantly associated with PL, and Sharpea and Helicobacter exhibited significant association with IMF (p < 0.05). Furthermore, Paraprevotella was also identified as a critical microbe affecting PL based on the divergent Wilcoxon rank-sum test. Overall, this study reveals the effect of host genetics and gut microbiome on pig fat deposition traits and provides a new perspective on the genetic improvement of pig fat deposition traits. Frontiers Media S.A. 2022-09-20 /pmc/articles/PMC9530793/ /pubmed/36204621 http://dx.doi.org/10.3389/fmicb.2022.925200 Text en Copyright © 2022 Wang, Zhou, Zhou, Fu, Wang, Liu, Liu, Wang and Liu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Wang, Yuan
Zhou, Ping
Zhou, Xiang
Fu, Ming
Wang, Tengfei
Liu, Zuhong
Liu, Xiaolei
Wang, Zhiquan
Liu, Bang
Effect of host genetics and gut microbiome on fat deposition traits in pigs
title Effect of host genetics and gut microbiome on fat deposition traits in pigs
title_full Effect of host genetics and gut microbiome on fat deposition traits in pigs
title_fullStr Effect of host genetics and gut microbiome on fat deposition traits in pigs
title_full_unstemmed Effect of host genetics and gut microbiome on fat deposition traits in pigs
title_short Effect of host genetics and gut microbiome on fat deposition traits in pigs
title_sort effect of host genetics and gut microbiome on fat deposition traits in pigs
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9530793/
https://www.ncbi.nlm.nih.gov/pubmed/36204621
http://dx.doi.org/10.3389/fmicb.2022.925200
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