Brca1 (L63X) (/+) rat is a novel model of human BRCA1 deficiency displaying susceptibility to radiation‐induced mammary cancer

Women who are heterozygous for deleterious BRCA1 germline mutations harbor a high risk of hereditary breast cancer. Previous Brca1‐heterozygous animal models do not recapitulate the breast cancer phenotype, and thus all currently used knockout models adopt conditional, mammary‐specific homozygous Br...

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Detalles Bibliográficos
Autores principales: Nakamura, Yuzuki, Kubota, Jo, Nishimura, Yukiko, Nagata, Kento, Nishimura, Mayumi, Daino, Kazuhiro, Ishikawa, Atsuko, Kaneko, Takehito, Mashimo, Tomoji, Kokubo, Toshiaki, Takabatake, Masaru, Inoue, Kazumasa, Fukushi, Masahiro, Arai, Masami, Saito, Mitsue, Shimada, Yoshiya, Kakinuma, Shizuko, Imaoka, Tatsuhiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9530872/
https://www.ncbi.nlm.nih.gov/pubmed/35851737
http://dx.doi.org/10.1111/cas.15485

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9530872/
https://www.ncbi.nlm.nih.gov/pubmed/35851737
http://dx.doi.org/10.1111/cas.15485

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