Synergistic Associations of PNPLA3 I148M Variant, Alcohol Intake, and Obesity With Risk of Cirrhosis, Hepatocellular Carcinoma, and Mortality

IMPORTANCE: Alcohol drinking and obesity are associated with an increased risk of cirrhosis and hepatocellular carcinoma (HCC), but the risk is not uniform among people with these risk factors. Genetic variants, such as I148M in the patatin-like phospholipase domain-containing protein 3 (PNPLA3) gen...

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Detalles Bibliográficos
Autores principales: Kim, Hyun-seok, Xiao, Xiangjun, Byun, Jinyoung, Jun, Goo, DeSantis, Stacia M., Chen, Han, Thrift, Aaron P., El-Serag, Hashem B., Kanwal, Fasiha, Amos, Christopher I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Medical Association 2022
Materias:
Original Investigation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9530967/
https://www.ncbi.nlm.nih.gov/pubmed/36190732
http://dx.doi.org/10.1001/jamanetworkopen.2022.34221

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9530967/
https://www.ncbi.nlm.nih.gov/pubmed/36190732
http://dx.doi.org/10.1001/jamanetworkopen.2022.34221

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