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Synergistic Associations of PNPLA3 I148M Variant, Alcohol Intake, and Obesity With Risk of Cirrhosis, Hepatocellular Carcinoma, and Mortality
IMPORTANCE: Alcohol drinking and obesity are associated with an increased risk of cirrhosis and hepatocellular carcinoma (HCC), but the risk is not uniform among people with these risk factors. Genetic variants, such as I148M in the patatin-like phospholipase domain-containing protein 3 (PNPLA3) gen...
Autores principales: | Kim, Hyun-seok, Xiao, Xiangjun, Byun, Jinyoung, Jun, Goo, DeSantis, Stacia M., Chen, Han, Thrift, Aaron P., El-Serag, Hashem B., Kanwal, Fasiha, Amos, Christopher I. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Medical Association
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9530967/ https://www.ncbi.nlm.nih.gov/pubmed/36190732 http://dx.doi.org/10.1001/jamanetworkopen.2022.34221 |
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