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Proteotoxic stress-induced apoptosis in cancer cells: understanding the susceptibility and enhancing the potency
Leiomyosarcoma (LMS) is aggressive cancer with few therapeutic options. LMS cells are more sensitive to proteotoxic stress compared to normal smooth muscle cells. We used small compound 2c to induce proteotoxic stress and compare the transcriptomic adaptations of immortalized human uterine smooth mu...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9531228/ https://www.ncbi.nlm.nih.gov/pubmed/36195608 http://dx.doi.org/10.1038/s41420-022-01202-2 |