Proteotoxic stress-induced apoptosis in cancer cells: understanding the susceptibility and enhancing the potency

Leiomyosarcoma (LMS) is aggressive cancer with few therapeutic options. LMS cells are more sensitive to proteotoxic stress compared to normal smooth muscle cells. We used small compound 2c to induce proteotoxic stress and compare the transcriptomic adaptations of immortalized human uterine smooth mu...

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Detalles Bibliográficos
Autores principales: Iuliano, Luca, Dalla, Emiliano, Picco, Raffaella, Mallavarapu, Showmeya, Minisini, Martina, Malavasi, Eleonora, Brancolini, Claudio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9531228/
https://www.ncbi.nlm.nih.gov/pubmed/36195608
http://dx.doi.org/10.1038/s41420-022-01202-2

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