Posttranslational S-nitrosylation modification regulates HMGB1 secretion and promotes its proinflammatory and neurodegenerative effects

Nuclear protein high-mobility group box 1 (HMGB1) can be actively secreted by activated immune cells and functions as a proinflammatory cytokine. Regulation of HMGB1 secretion is critical for treatment of HMGB1-mediated inflammation and related diseases. This study demonstrates that S-nitrosylation...

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Detalles Bibliográficos
Autores principales: Yang, Ru, Gao, Yun, Li, Hui, Huang, Wei, Tu, Dezhen, Yang, Mengnan, Liu, Xingqian, Hong, Jau-Shyong, Gao, Hui-Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9531316/
https://www.ncbi.nlm.nih.gov/pubmed/36103834
http://dx.doi.org/10.1016/j.celrep.2022.111330

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9531316/
https://www.ncbi.nlm.nih.gov/pubmed/36103834
http://dx.doi.org/10.1016/j.celrep.2022.111330

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