VHHs as tools for therapeutic protein delivery to the central nervous system

BACKGROUND: The blood brain barrier (BBB) limits the therapeutic perspective for central nervous system (CNS) disorders. Previously we found an anti-mouse transferrin receptor (TfR) VHH (Nb62) that was able to deliver a biologically active neuropeptide into the CNS in mice. Here, we aimed to test it...

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Detalles Bibliográficos
Autores principales: Wouters, Yessica, Jaspers, Tom, Rué, Laura, Serneels, Lutgarde, De Strooper, Bart, Dewilde, Maarten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9531356/
https://www.ncbi.nlm.nih.gov/pubmed/36192747
http://dx.doi.org/10.1186/s12987-022-00374-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9531356/
https://www.ncbi.nlm.nih.gov/pubmed/36192747
http://dx.doi.org/10.1186/s12987-022-00374-4

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