Phase II Study of Ponatinib in Advanced Gastrointestinal Stromal Tumors: Efficacy, Safety, and Impact of Liquid Biopsy and Other Biomarkers

PURPOSE: The purpose of this study is to evaluate ponatinib for advanced gastrointestinal stromal tumors (GIST). PATIENTS AND METHODS: This single-arm phase II trial enrolled patients with metastatic and/or unresectable GIST with failure of prior tyrosine kinase inhibitor (TKI) treatment into two co...

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Detalles Bibliográficos
Autores principales: George, Suzanne, von Mehren, Margaret, Fletcher, Jonathan A., Sun, Jichao, Zhang, Sen, Pritchard, Justin R., Hodgson, John Graeme, Kerstein, David, Rivera, Victor M., Haluska, Frank G., Heinrich, Michael C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2022
Materias:
Clinical Trials: Targeted Therapy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9531534/
https://www.ncbi.nlm.nih.gov/pubmed/35091442
http://dx.doi.org/10.1158/1078-0432.CCR-21-2037

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9531534/
https://www.ncbi.nlm.nih.gov/pubmed/35091442
http://dx.doi.org/10.1158/1078-0432.CCR-21-2037

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