Distinct phosphorylation states of mammalian CaMKIIβ control the induction and maintenance of sleep

The reduced sleep duration previously observed in Camk2b knockout mice revealed a role for Ca(2+)/calmodulin-dependent protein kinase II (CaMKII)β as a sleep-promoting kinase. However, the underlying mechanism by which CaMKIIβ supports sleep regulation is largely unknown. Here, we demonstrate that a...

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Detalles Bibliográficos
Autores principales: Tone, Daisuke, Ode, Koji L., Zhang, Qianhui, Fujishima, Hiroshi, Yamada, Rikuhiro G., Nagashima, Yoshiki, Matsumoto, Katsuhiko, Wen, Zhiqing, Yoshida, Shota Y., Mitani, Tomoki T., Arisato, Yuki, Ohno, Rei-ichiro, Ukai-Tadenuma, Maki, Yoshida Garçon, Junko, Kaneko, Mari, Shi, Shoi, Ukai, Hideki, Miyamichi, Kazunari, Okada, Takashi, Sumiyama, Kenta, Kiyonari, Hiroshi, Ueda, Hiroki R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9531794/
https://www.ncbi.nlm.nih.gov/pubmed/36194579
http://dx.doi.org/10.1371/journal.pbio.3001813

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9531794/
https://www.ncbi.nlm.nih.gov/pubmed/36194579
http://dx.doi.org/10.1371/journal.pbio.3001813

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