Dexmedetomidine exerts an anti-inflammatory effect via α2 adrenoceptors to alleviate cognitive dysfunction in 5xFAD mice

Background: Inflammation promotes the progression of Alzheimer’s disease (AD). In this study, we explored the effect of dexmedetomidine on inflammation and cognitive function in a mouse model of AD. Methods: 5xFAD mice were intragastrically administered saline, dexmedetomidine, or dexmedetomidine an...

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Detalles Bibliográficos
Autores principales: Luo, Su-mei, Li, Long-yan, Guo, Li-zhe, Wang, Lu, Wang, Yan-feng, Chen, Na, Wang, E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Aging Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9531904/
https://www.ncbi.nlm.nih.gov/pubmed/36204551
http://dx.doi.org/10.3389/fnagi.2022.978768

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9531904/
https://www.ncbi.nlm.nih.gov/pubmed/36204551
http://dx.doi.org/10.3389/fnagi.2022.978768

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