Emerging Therapies for Huntington’s Disease – Focus on N-Terminal Huntingtin and Huntingtin Exon 1

Huntington’s disease is a devastating heritable neurodegenerative disorder that is caused by the presence of a trinucleotide CAG repeat expansion in the Huntingtin gene, leading to a polyglutamine tract in the protein. Various mechanisms lead to the production of N-terminal Huntingtin protein fragme...

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Detalles Bibliográficos
Autores principales: van der Bent, M Leontien, Evers, Melvin M, Vallès, Astrid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9532260/
https://www.ncbi.nlm.nih.gov/pubmed/36213816
http://dx.doi.org/10.2147/BTT.S270657

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9532260/
https://www.ncbi.nlm.nih.gov/pubmed/36213816
http://dx.doi.org/10.2147/BTT.S270657

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