Cargando…

Identification of distinct functional thymic programming of fetal and pediatric human γδ thymocytes via single-cell analysis

Developmental thymic waves of innate-like and adaptive-like γδ T cells have been described, but the current understanding of γδ T cell development is mainly limited to mouse models. Here, we combine single cell (sc) RNA gene expression and sc γδ T cell receptor (TCR) sequencing on fetal and pediatri...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sanchez Sanchez, Guillem, Papadopoulou, Maria, Azouz, Abdulkader, Tafesse, Yohannes, Mishra, Archita, Chan, Jerry K. Y., Fan, Yiping, Verdebout, Isoline, Porco, Silvana, Libert, Frédérick, Ginhoux, Florent, Vandekerckhove, Bart, Goriely, Stanislas, Vermijlen, David
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9532436/ https://www.ncbi.nlm.nih.gov/pubmed/36195611 http://dx.doi.org/10.1038/s41467-022-33488-2

Ejemplares similares

γδIL17 under control
por: Sanchez Sanchez, Guillem, et al.
Publicado: (2022)

The human fetal thymus generates invariant effector γδ T cells
por: Tieppo, Paola, et al.
Publicado: (2019)

JNK1 Signaling Downstream of the EGFR Pathway Contributes to Aldara(®)-Induced Skin Inflammation
por: Le, Aurore, et al.
Publicado: (2021)

Thymic exosomes promote the final maturation of thymocytes
por: Lundberg, Vanja, et al.
Publicado: (2016)

Effects of sex steroids on thymic epithelium and thymocyte development
por: Taves, Matthew D., et al.
Publicado: (2022)

Aire Disruption Influences the Medullary Thymic Epithelial Cell Transcriptome and Interaction With Thymocytes
por: Speck-Hernandez, Cesar A., et al.
Publicado: (2018)

Chronic CD27-CD70 costimulation promotes type 1-specific polarization of effector Tregs
por: Bowakim-Anta, Natalia, et al.
Publicado: (2023)

Mechanisms Involved in the Binding of Thymocytes to Rat Thymic Dendritic Cells
por: Čolić, Miodrag, et al.
Publicado: (1996)

Intercellular Protein Transfer from Thymocytes to Thymic Epithelial Cells
por: Wang, Hong-Xia, et al.
Publicado: (2016)

Distinct subpopulations of DN1 thymocytes exhibit preferential γδ T lineage potential
por: Oh, Seungyoul, et al.
Publicado: (2023)

Strong TCRγδ Signaling Prohibits Thymic Development of IL-17A-Secreting γδ T Cells
por: Sumaria, Nital, et al.
Publicado: (2017)

The oxygen sensor prolyl hydroxylase domain 2 regulates the in vivo suppressive capacity of regulatory T cells
por: Ajouaou, Yousra, et al.
Publicado: (2022)

Thymic Program Directing the Functional Development of γδT17 Cells
por: Jouan, Youenn, et al.
Publicado: (2018)

An anti-DEC-205 monoclonal antibody stimulates binding of thymocytes to rat thymic dendritic cells and promotes apoptosis of thymocytes
por: Majstorović, Ivana, et al.
Publicado: (2014)

Role of β2 Integrins in the Binding of Thymocytes to Rat Thymic Macrophages
por: Čolić, Miodrag, et al.
Publicado: (1994)

Bidirectional Interactions Between Thymocytes and Thymic Epithelial Cell Lines in Vitro
por: Čolić, Miodrag, et al.
Publicado: (1998)

A novel integrin involved in thymocyte-thymic epithelial cell interactions
Publicado: (1991)

Thymic Microenvironment: Interactions Between Innate Immune Cells and Developing Thymocytes
por: Wang, Helen, et al.
Publicado: (2022)

In vitro maturation of immature thymocytes into immunocompetent T cells in the absence of direct thymic influence
por: Irle, C, et al.
Publicado: (1978)

Antigen Recognition By Autoreactive Cd4(+) Thymocytes Drives Homeostasis Of The Thymic Medulla
por: Irla, Magali, et al.
Publicado: (2012)

Maturation and migration of murine CD4 single positive thymocytes and thymic emigrants
por: Xu, Xi, et al.
Publicado: (2014)

Inhibins Tune the Thymocyte Selection Process by Regulating Thymic Stromal Cell Differentiation
por: Carbajal-Franco, Ebzadrel, et al.
Publicado: (2015)

How Many Thymic Epithelial Cells Are Necessary for a Proper Maturation of Thymocytes?
por: Montero-Herradón, Sara, et al.
Publicado: (2021)

Type I interferons regulate eomesodermin expression and the development of unconventional memory CD8(+) T cells
por: Martinet, Valérie, et al.
Publicado: (2015)

The actin remodeling protein cofilin is crucial for thymic αβ but not γδ T-cell development
por: Seeland, Isabel, et al.
Publicado: (2018)

Different Subpopulations of Developing Thymocytes are Associated with Adherent (Macrophage) or Nonadherent (Dendritic) Thymic Rosettes
por: Shortman, Ken, et al.
Publicado: (1991)

Seeding of thymic microenvironments defined by distinct thymocyte- stromal cell interactions is developmentally controlled
Publicado: (1987)

Transcriptome analysis of murine thymocytes reveals age-associated changes in thymic gene expression
por: Lustig, Ana, et al.
Publicado: (2009)

The thymic medulla is required for Foxp3(+) regulatory but not conventional CD4(+) thymocyte development
por: Cowan, Jennifer E., et al.
Publicado: (2013)

Fibronectin modulates thymocyte-thymic epithelial cell interactions following Trypanosoma cruzi infection
por: Farias-de-Oliveira, Désio Aurélio, et al.
Publicado: (2013)

Thymic tuft cells promote an IL4-enriched medulla and shape thymocyte development
por: Miller, Corey N., et al.
Publicado: (2018)

E-protein–regulated expression of CXCR4 adheres preselection thymocytes to the thymic cortex
por: Kadakia, Tejas, et al.
Publicado: (2019)

Critical role of SP thymocyte motility in regulation of thymic output in neonatal Aire(−/−) mice
por: Jin, Rong, et al.
Publicado: (2016)

Thymocytes trigger self-antigen-controlling pathways in immature medullary thymic epithelial stages
por: Lopes, Noella, et al.
Publicado: (2022)

Functional reprogramming of monocytes in patients with acute and convalescent severe COVID-19
por: Brauns, Elisa, et al.
Publicado: (2022)

EOMES interacts with RUNX3 and BRG1 to promote innate memory cell formation through epigenetic reprogramming
por: Istaces, Nicolas, et al.
Publicado: (2019)

Human cytomegalovirus elicits fetal γδ T cell responses in utero
por: Vermijlen, David, et al.
Publicado: (2010)

Characterization of Adaptive-like γδ T Cells in Ugandan Infants during Primary Cytomegalovirus Infection
por: Tuengel, Jessica, et al.
Publicado: (2021)

TCR signal strength controls thymic differentiation of discrete proinflammatory γδ T cell subsets
por: Muñoz-Ruiz, Miguel, et al.
Publicado: (2016)

Human Thymic Epithelial Cells in Serum-Free Culture: Nature and Effects on Thymocyte Cell Lines
por: Ropke, Carsten, et al.
Publicado: (1992)

Cannot write session to /tmp/vufind_sessions/sess_1cchj9betpap1lj9m1kd7cb1pe